RIT of Non Hodgkins Lymphoma with Radiolabeled Antibodies

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TEST: RIT of non-Hodgkin’s Lymphoma with Radiolabeled Antibodies

1.  The most commonly occurring hematologic cancer is...?

         Leukemia

        T-cell lymphoma

        B-cell lymphoma

        Follicular Cell Lymphoma

2.  Of all new cases of NHL, what % are B-cell lymphomas...?

        15

        35

        65

        85

3.  What percent of B-cell lymphomas express the CD20 antigen?

        15

        35

        65

        90

4.    The 2nd most commonly occurring hematologic cancer is...?: 

        Leukemia

        T-cell lymphoma

        B-cell lymphoma

        Follicular cell lymphoma

5.     Which ONE of the following is NOT a principle of Radioimmunotherapy ...?

        Targeted delivery of radiation 

        Greater exposure of tumors vs. surrounding organs by virtue of the selectivity of the carrier antibody

        Potential for one-time instantaneous exposure of tumor cells

        Anti-tumor mechanisms of the antibody

6.   Bexxar and Zevalin are designed as...?:

        A single course of treatment

        A monthly course each month for four months

        Semi-annual treatments for three years

        None of the above

7.   The unified therapy regimen for Bexxar and Zevalin includes...:

        Only an IV infusion of the radioactive antibody

        Only an IV infusion of the non-radioactive antibody

        An IV infusion of the radioactive antibody followed by an  IV infusion of the non-radioactive antibody

        An IV infusion of the non-radioactive antibody followed by an  IV infusion of the radioactive antibody

7.   The unified therapy regimen for Bexxar and Zevalin includes...:

        Only an IV infusion of the radioactive antibody

        Only an IV infusion of the non-radioactive antibody

        An IV infusion of the radioactive antibody followed by an  IV infusion of the non-radioactive antibody

        An IV infusion of the non-radioactive antibody followed by an  IV infusion of the radioactive antibody

8.   Patient preparation for Zevalin therapy includes...:

        a:  Thyroid blockage with non-radioactive iodine from one day before Zevalin administration until 14 days after administration

        b:  Acetaminophen and benadryl on a daily basis for 10 days

        c:  Acetaminophen and benadryl on the day of drug administration only

        a and c only

9.   Patient preparation for Bexxar therapy includes...?:

        a:  Thyroid blockage with non-radioactive iodine from one day before Zevalin administration until 14 days after administration

          b:  Acetaminophen and benadryl on a daily basis for 10 days

         c:  Acetaminophen and benadryl on the day of drug administration only

        a and c only

10. Bexxar and Zevalin therapeutic doses are labeled with _______ and _______, respectively...?

        I-131 and In-111

        I-125 and Cd-111

        I-131 and Y-90

        None of the above  

11.  Which one of the following statements is true...?

        Bexxar requires special radiation shielding because, unlike Xevalin,  the beta-emitter used in Bexxar also emits many gamma-rays

        Zevalin requires special radiation shielding because, unlike Bexxar,  the beta-emitter used in Zevalin also emits many gamma-rays

        Both labeled antibodies are labeled with isotopes that are pure alpha- emitters

        Neither of the two isotopes is a pure beta-emitter

11.  Which one of the following statements is true...?

        Bexxar requires special radiation shielding because, unlike Xevalin,  the beta-emitter used in Bexxar also emits many gamma-rays

        Zevalin requires special radiation shielding because, unlike Bexxar,  the beta-emitter used in Zevalin also emits many gamma-rays

        Both labeled antibodies are labeled with isotopes that are pure alpha- emitters

        Neither of the two isotopes is a pure beta-emitter

12.  What is the purpose of administering the unlabeled antibody prior to administration of Bexxar or Zevalin...?

        a:  Reduces splenic uptake

        b:  Increases terminal half-life of the radiolabeled antibody

        a and c

        None of the above

13. For Bexxar, the goal is to deliver a whole body dose of...?

        .75 cGy

        7.5 cGy

        75 cGy

        750 cGy

14. Following Bexxar therapy in patients with CD20 positive refractory or relapsed follicular, low grade, or relapsed NHL, overall response rates ranged from...?

        5-11 %

        18-29%

        47-68%

        92-99%

15.      HAMA stands for...?

        Health and Mental Attitude

        Human Anti-Melanoma Antibody

        Human Anti-Mouse Antibody

        Herceptin Accelerated Modulated Antibody

16.      Which of the following render(s) a patient ineligible for RIT Therapy?

        a:  Pregnant or nursing women

        b:  Bone marrow involvement >10%

        c:   Platelet count of 250,000

        a and c above

17. Which one of the following statements is TRUE...?

        The incidence of NHL has been increasing lately, especially in young people

        The incidence of NHL has been decreasing lately, especially in young people

        The incidence of NHL has been increasing lately, especially in older people

        The incidence of NHL has been decreasing lately, especially in older people

18. Rituximab, the unlabeled antibody, has...?

        a:  been shown to be an effective treatment for certain forms of NHL

        b:  been approved by the FDA for treatment for certain forms of NHL

        a and b are correct

        none of the above

19. When using Zevalin, the following protocol is followed...?

        5 mCi dosimetric dose of I-131 Zevalin; 50 mCi therapeutic dose of I-131 Zevalin

        5 mCi dosimetric dose of Y-90 Zevalin; 50 mCi therapeutic dose of Y-90 Zevalin

        5 mCi dosimetric dose of In-111 Zevalin; 32 mCi therapeutic dose of Y-90 Zevalin

        5 mCi dosimetric dose of I-131 Zevalin; 50 mCi therapeutic dose of I-131 Zevalin

20.  The maximum dose of Zevalin that may be injected is ...?

        3 mCi

        32 mCi

        75 mCi

        100 mCi

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