Molecular Imaging

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1.  Development of ________________ in the late sixteenth century led to a keen interest in observations of structure of tissues and organs:

        practical methods of surgical autopsy

        effective anesthesia

        the first microscope

        the scientific method

2.  Molecular Imaging is defined as...:

        The spatially localized and/or temporally resolved sensing of molecular and cellular processes in vivo.

        The temporally localized and/or spatially resolved sensing of molecular and cellular processes in vivo.

        The spatially localized and/or temporally resolved sensing of molecular and cellular processes in vitro

        The temporally localized and/or spatially resolved sensing of molecular and cellular processes in vitro.

3.  Which ONE of the following statements is FALSE?

        Molecular imaging originated from the field of anatomy due to the need to better understand the fundamental molecular pathways inside organisms in a noninvasive manner

        Molecular imaging originated from the field of radiopharmacology due to the need to better understand the fundamental molecular pathways inside organisms in a noninvasive manner

        Molecular imaging unites molecular biology and in vivo imaging and enables the visualization of cellular function and the follow-up of the molecular process in living organisms without perturbing them.

        Molecular Imaging is multidisciplinary and involves utilization of a variety of imaging techniques.

4.   Which of the following is NOT an example of Molecular Imaging?:

        Tc-MAA for pulmonary perfusion studies

        Tc-RBCs for Blood Pool Imaging      

        Tc-MDP for Bone Scan

        MAA and RBC's only

        All of the above

5.     Which of the following is NOT an example of Molecular Imaging?:

        Tc-MDP for Bone Scan

        Tc-Sulfur Colloid for Liver Scan

        I-123 mIBG for Neuroendocrine Tumor Imaging

        Rb-82 Ion for Myocardial Perfusion Study

        None of the above

6.   Which of the following IS an example of Molecular Imaging...:

        I-131 NaI for Therapy of Hyperthyroidism

        I-131 Bexxar for Therapy of NHL

        In-111 Octreoscan for Imaging Carcinoid

        Bexxar only

        All of the Above
         

7.   Working on a molecular level results in... :

        Earlier detection of certain diseases than with other imaging modalities

        Later detection of certain diseases than with other imaging modalities

        Time of detection comparable to that of radiographic study

        An increased incidence of unnecessary surgeries
 

8.   The goals of Molecular Imaging include all of the following except...:

        To develop noninvasive in vitro imaging methods that reflect specific cellular and molecular processes

        To monitor multiple molecular events near-simultaneously

        To optimize drug and gene therapy

        To image drug effects at a molecular and cellular level
 

9.    Molecular Imaging permits...: 

        Temporal but not spatial resolution of a molecular probe

         Spatial but not temporal resolution of a molecular probe

         Both  temporal and spatial resolution of a molecular probe

        Neither temporal nor spatial resolution of a molecular probe
 

10.    Why is Tc-SC for RES Imaging NOT an example of a molecular probe?: 

        Tc-SC is not a molecule

         Tc-SC is not a probe

          Its uptake is based strictly on particle size and not on chemical composition of the radiotracer

        Its uptake is based upon a chemical attraction of sulfur particles for Kupffer cells in the liver

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