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Test: Radioisotope Generators

1. The Tc99m eluted from the Mo99/Tc99m generator is in the chemical form of?:

        Technetium sulfate, e.g. Tc(SO4)2

        Technetium hydroxide, e.g. Tc(OH)4

        Hydrolyzed reduced Tc, e.g. TcO(OH)2.(H2O)

        Pertechnetate (Tc04)

2. The parent/daughter relationship in a Mo/Tc generator is a classical example of...

        Dynamic stability

        Secular equilibrium

        Transient equilibrium

        Reverse isomeric transition

3. Which one of the following is true for transient equilibrium:

        The physical half-life of the daughter equals the physical half-life of the parent

        The physical half-life of the daughter is 10 times the physical half-life of the parent

        The apparent half-life of the daughter equals the physical half-life of the parent

        The apparent half-life of the parent equals the physical half-life of the daughter

4. In the Mo/Tc generator, separation of the daughter from the parent is based upon...

        Electrophoretic separation

        Gravity separation

        In-vivo separation

        Chromatographic separation

5. The chromatography column in a Mo99/Tc99m generator contains...

        Aluminum oxide

        Aluminum chlorohydrate

        Aluminum hydroxide

        Silica gel

6. The Mo/Tc generator is eluted with...

        0.001M hydrochloric acid

        Sterile distilled water

        Physiological saline

        None of the above

7. We analyze the generator eluate for impurities. These include...

        Free Tc, Al3+ ion, Mo99

        Free Tc, Mo99, Hydrolyzed Reduced Tc

        Perchlorate, molybdate

        Al3+, Mo99, Hydrolyzed Reduced Tc

8. After a molybdenum99/technetium99m generator is eluted with typical efficiency, the in-growing Tc99m reaches a maximum at...

        At about 2 hours

        Between 2 and 6 hours

        Between 12 and 24 hours

        Only after 30 hours

9. In an equilibrium mixture of parent molybdenum99 and daughter Tc99m, the ratio of Tc99m activity to Mo99 activity is:

        About 0.7

        About 1.5

        Greater than 2

        About 1.1

10. Tc99m formed in the Mo/Tc generator decays to radioactive Tc99g which has a half life of 2.1 x105 years. Tc99g does not contribute significantly to absorbed dose in in vivo procedures because:

        The number of atoms of Tc99g is small compared with the number of atoms of Tc99m

        Tc99g does not emit particulate radiation as it decays

        It is rapidly cleared from the body

        The activity of Tc99g is small compared with the activity of Tc99m

11. Which one of the following is essential for a practical laboratory radionuclide generator?

        Daughter must have a longer half-life than parent

        Daughter must have a shorter half-life than parent

        Daughter half-life must not be less than one hour

        Parent must not decay to daughter by isobaric transition

12.  In the Mo/Tc generator, the elution of technetium by saline solution produces a separation from molybdenum because...

        The molybdenum is in the form of insoluble metal

        The molybdenum chloride is insoluble

        The molybdate is absorbed on alumina, whereas pertechnetate is not

        None of the above

13.  What is the limit of aluminum ion concentration in Na pertechnetate solution produced by a fission Mo generator?

        l00 цg per ml

        20 цg per ml

        l0 цg per ml

        2 цg per ml

14.  The radionuclide impurities in Tc-99m pertechnetate eluate can be determined by...?

        GM counter

        Thin Layer Chromatography

        Dose Calibrator

        Cutie Pie

15.  The legal limit for Mo-99 breakthrough is...

        1 цCi Mo99/mCi  Tc99m at time of elution

        1 цCi Mo99/mCi  Tc99m at time of injection

        0.15 цCi Mo99/mCi  Tc99m at time of elution

        0.15 цCi Mo99/mCi Tc99m at time of administration

16.  The Tc99m eluate at 7:00 A.M. this morning had a ratio of 0.10 mCi Mo99/mCi Tc99m. Which one of the following is true?

        This ratio decreases as a function of time

        If the generator were eluted again at 8:00 A.M., no activity would be obtained

        Most departments determine this ratio using a radioisotope dose calibrator

        Equilibrium is reached 12 hours after the previous elution

17.  For the existence of radioactive equilibrium...

        Half-life of the parent must be greater than the half-life of the daughter

        Daughter must decay by isomeric transition

        Parent must decay by beta-minus decay

        Daughter must be stable

18.  In transient equilibrium, the ratio of parent’s half-life to daughter’s half-life is approximately

        1

        10

        50

        1000

19.  A Mo99/Tc99m generator has a useful life of

        1 Day

        1 Week

        2 Weeks

        1 Month

20.  The cylindrical lead shielding in a Mo/Tc generator is 2 inches thick and weighs approximately 48 pounds. This large quantity of lead is required to shield...

        The Tc99m

        The Mo99

        Both the Mo and the Tc

        Neither of these isotopes

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