Neuroendocrine Tumor Imaging

•   I-123 mIBG and I-131 mIBG   Clinical Issues
   

  • INDICATIONS FOR CLINICAL STUDIES
     

    • Pheochromocytoma
       
    • Neuroblastoma
       
    • Paraganglioma
       
    • Medullary carcinoma of the thyroid
       
    • Carcinoid tumors
       
    • Medullary hyperplasia of adrenals
       

  • EPIDEMIOLOGY
     

    • 0.1-0.5% of all hypertensives have a pheochromocytoma
       
    • Occurs in both sexes at all ages. The younger the patient, the more likely the disease is familial
       
    • Neuroblastoma is the second leading cause of death in children due to cancer
       
    • Epidemiology
       
    • Family history of certain syndromes associated with high incidence of pheochromocytoma, e.g., Neurofibromatosis, Multiple Endocrine Neuroplasia Syndrome (MEN), Von-Hipple Lindau disease
       

  • DIAGNOSTIC PATTERNS
     

    • Family History
       
    • Symptoms
       
    • Clinical Data, for example
       
    • Sustained or labile hypertension, unusually severe, markedly labile spells
       
    • Hypertension plus spells (include sweating, palpitations, headache)
       

  • THE 10% RULES FOR PHEOCHROMOCYTOMAS
     

    • 10% Multiple
       

    • 10% Extra Adrenal
       

    • 10% Bilateral
       

    • 10% Familial
       

    • 10% Malignant