In Vivo Non Imaging Procedures:

SPLENIC SEQUESTRATION STUDY

PROCEDURE

• Cr-51 labeled autologous RBC's are reinjected into the patient.
   
• Using a collimated sodium iodide crystal, counts/5 min are taken over the liver, spleen, and precordium on a daily basis for 7-10 days.
   
• Spleen:liver and spleen:heart ratio are calculated for each point in time.
  
   

  
   

INTERPRETATION

• Spleen:liver ratio and spleen:heart ratio are normally approximately 1:1.
   
• Values up to 2:1 may indicate splenomegaly.
   
• Ratios > 2.5:1 suggest significant splenic sequestration. The patient may benefit from splenectomy or partial splenic embolization.

LIMITATION

• Procedure is very time-consuming, since patient must return and be counted for up to 14 days