RADIONUCLIDE GENERATORS AND EQUILIBRIUM

After studying this tutorial and taking the test, one should be able to describe the two different types of equilibrium and explain the relationship between radionuclide generators and equilibrium; should be able to give examples of each type of generator and explain the principles of separation of daughter from parent; should be able to define the term “generator” and to list the properties of the ideal generator system; should be able to identify the parts of the Mo-99/Tc-99m generator and explain the elution process; and should be able to identify the two clinically useful generators sold in the US;


1.  Definition of Parent-Daughter Equilibrium

          a. Secular Equilibrium

          b. Transient Equilibrium

2. Definition of a Generator

3. Properties of the Ideal Generator System

4. Design of a Mo/Tc Generator Column

5. Principles of Operation of a Radionuclide Generator

6. Clinically Useful Radionuclide Generators

7.  Genealogy of Mo-99

8.  Miscellaneous Information