Part 4: Radionuclide Generators,
Generator QC
1. The
Tc-99m eluted from the Mo‑99/Tc-99m generator is in the chemical form of
a) pertechnetate
(Tc04)
b) hydrolyzed
reduced Tc, e.g. Tc0(OH)2.(H20)
c) Technetium
hydroxide, e.g. Tc(OH)4
d) Technetium
sulfate, e.g. Tc(S04)2
e) None
of the above
2. The parent/daughter relationship in a Mo/Tc
generator is a classical example of
a) dynamic
stability
b) secular
equilibrium
c) transient
equilibrium
d) reverse
isomeric transition
e) none
of the above
3. Which of the following is/are true for transient
equilibrium:
a)
at equilibrium, the physical half-life of the daughter equals the
physical half-life of the parent
b)
at equilibrium, the physical half-life of the daughter is 10 times as
great as the physical half-life of the parent
c)
at equilibrium, the apparent half-life of the parent equals the physical
half-life of the daughter
d)
at equilibrium, the apparent half-life of the daughter equals the
physical half-life of the parent
e) none
of the above
4. In the Mo/Tc generator, separation of the daughter
from the parent is based on
a) electrophoretic
separation
b) gravity
separation
c) in-vivo
separation
d) chromatographic
separation
5. The chromatography column in a Mo-99/Tc-99m
generator contains
a) aluminum
chlorohydrate
b) aluminum
hydroxide
c) aluminum
oxide
d) silica
gel
e) none
of the above
6. The Mo/Tc generator is eluted with
a) 0.001M
hydrochloric acid
b) sterile
distilled water
c) physiological
saline
d) none
of the above
7. We analyze the generator eluate for
impurities. These include
a) free
Tc, Al3+ ion, Mo99
b) free
Tc, Mo99, Hydrolyzed Reduced Tc
c) Al3+
, Mo99, Hydrolyzed Reduced Tc
d) free
Tc, Hydrolyzed Reduced Tc
e) perchlorate,
molybdate
8.
After a molybdenum-99/technetium-99m generator is eluted with typical
efficiency, the in-growing Tc-99m reaches a maximum
a. at about 2 hours
b. between 2 and 6 hours
c. between 6 and 12 hours
d. between 12 and 24 hours
e. only after 30 hours
9.
In an equilibrium mixture of parent molybdenum-99 and daughter Tc-99m,
the ratio of Tc-99m activity to Mo-99 activity is:
a. greater than 2
b. about 1.5
c. about 1.1
d. about 0.98
e. about 0.7
10.
Tc-99m formed in the Mo/Tc generator decays to radioactive Tc-99g which
has a half life of 2.1 x105 years. Tc-99g does not contribute
significantly to absorbed dose in in vivo procedures because:
a. Tc-99g
does not emit particulate radiation as it decays
b. It
is rapidly cleared from the body
c.
The number of atoms of 99gTc is small compared with the number
of atoms of 99mTc
d. The
activity of Tc-99g is small compared with the activity of Tc-99m
11. Which of the following are essential for a practical
laboratory radionuclide generator?
a. Daughter
must have a longer half life than parent
b. Daughter
must have a shorter half life than parent
c. Daughter
half life must not be less than one hour
d. Parent
must not decay to daughter by isomeric transition
e. Parent
must not decay to daughter by isobaric transition
12.
In the Mo/Tc generator, the elution of technetium by saline solution
produces a separation from molybdenum because:
a. The molybdenum is in the form of insoluble metal
b. The molybdenum chloride is insoluble
c. The molybdate is absorbed on alumina, whereas
pertechnetate is not
d. None of the above
13.
What is the limit of aluminum ion concentration in Na pertechnetate
solution produced by a fission Mo generator?
a. 100
mg
per ml
b. 20
mg
per ml
c. 1
mg
per ml
d. 2
mg
per ml
e. 10
mg
per ml
14. The radionuclide impurities in Tc-99m
pertechnetate eluate can be determined by
a.
dose calibrator
b.
GM counter
c.
multichannel analyzer
d.
Cutie Pie
15.
The legal limit for Mo-99 breakthrough is
a.
1 mCi Mo-99/mCi Tc-99m at time of
elution
b.
1 mCi Mo-99/mCi Tc-99m at time of
injection
c.
0.15 mCi Mo-99/mCi Tc-99m at time
of elution
d.
0.15 mCi Mo-99/mCi Tc-99m at time
of administration
e.
None of the above
16.
The Tc-99m eluate at 7:00 A.M. this morning had a ratio of 0.10 mCi Mo-99/mCi Tc-99m. Mark the following statements
True/False:
a.
This ratio decreases as a function of time
b.
If the generator were eluted again at 8:00 A.M., no activity would be
obtained due to a shortened waiting period
c.
It would it be permissible to use this product in humans at 10:00 A.M.
d.
Equilibrium is reached 12 hours after the previous elution
17. For the existence of radioactive equilibrium,
True/False:
a) half-life
of the parent is greater than the half‑life of the daughter
b) number
of atoms of the parent exceeds the number of atoms of the daughter.
c) parent
must decay to a metastable state of the daughter
d) daughter
must be stable
18.
In transient equilibrium, the ratio of parent’s half-life to
daughter’s half-life is approximately
a)
1
b)
10
c)
50
d)
100
e)
1000
